This family incorporates just one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was found to methylate, in addition to histone, a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and components of the TATA binding protein (TBP) complicated, TBP-associated components TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Ok (goal lysine is daring), can be acknowledged by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of those substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a basic model for dynamic lysine methylation of each histone and non-histone proteins.

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N, amino terminus